Assessment of the anti-angiogenic,anti-inflammatory and antinociceptive properties of ethyl vanillin |
| |
| Authors: | Hyun-Joo Jung Yun Seon Song Kyunghoon Kim Chang-Jin Lim Eun-Hee Park |
| |
| Affiliation: | (1) College of Pharmacy, Sookmyung Women’s University, Seoul, 140-742, South Korea;(2) Department of Biochemistry and Research Institute of Life Sciences, Kangwon National University, Chuncheon, 200-701, South Korea;(3) Department of Health and Environment, Baekseok Culture University, Cheonan, 330-705, South Korea;(4) Department of Biological Sciences, Kangwon National University, Chuncheon, 200-701, South Korea;(5) Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea; |
| |
| Abstract: | The present work aimed to assess novel pharmacological properties of ethyl vanillin (EVA) which is used as a flavoring agent for cakes, dessert, confectionary, etc. EVA exhibited an inhibitory activity in the chorioallantoic membrane angiogenesis. Anti-inflammatory activity of EVA was convinced using the two in vivo models, such as vascular permeability and air pouch models in mice. Antinociceptive activity of EVA was assessed using acetic acid-induced writhing model in mice. EVA suppressed production of nitric oxide and induction of inducible nitric oxide synthase in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cells. However, EVA could not suppress induction of cyclooxygenase-2 in the LPS-activated macrophages. EVA diminished reactive oxygen species level in the LPS-activated macrophages. EVA also suppressed enhanced matrix metalloproteinase-9 gelatinolytic activity in the LPSactivated RAW264.7 macrophage cells. EVA at the used concentrations couldn’t diminish viability of the macrophage cells. Taken together, the anti-angiogenic, anti-inflammatory and anti-nociceptive properties of EVA are based on its suppressive effect on the production of nitric oxide possibly via decreasing the reactive oxygen species level. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
