达英-35联合强力霉素治疗女性迟发性痤疮临床疗效观察

目的观察达英-35联合强力霉素治疗女性迟发性痤疮的临床疗效。方法80例患者随机分为治疗组（41例）和对照组（39例），治疗组患者自月经来潮当晚开始口服达英-35，每天1片，3周为1个周期；停药1周，继续下个周期。强力霉素100mg，每天2次，4周后改为每天1次，服8周。对照组口服强力霉素，用法同治疗组。结果治疗组与对照组的治愈率分别为73．2％、33．3％，有效率为92．7％、58．9％，2组有效率差异有统计学意义（P〈0．05）。结论达英35联合强力霉素是治疗女性迟发性痤疮较好的疗法之一。

Clinical observation of the curative rate of Diane-35 plus Doxycycline in the treatment of late-onset female patients with Acne Vulgaris

Objective To evaluate the curative effect of Diane-35 plus Doxycycline in the treatment of late-onset female patients with Acne Vulgaris. Methods 80 female patients with late-onset Acne Vulgaris were randomly allocated to two groups ： a test group （ n = 41 ） and a control group （ n = 39 ）. The patients from the test group orally took Diane-35 once daily on the first day of menses for three weeks and stopped for one week as a complete cycle. Doxycycline 100mg twice daily for four weeks followed by once daily for eight weeks. The patients from the control group orally took Doxycycline 100mg twice daily for four weeks followed by once daily for eight weeks. Results The cure rate in the test group was 73.2% while the control group was 33.3%. The effective rate in the test group was 92.7% while the control group was 58.9%. There were statistical significant differences in above- mentioned two rates between the two groups （ P 〈 0.05 ）. Conclusion Diane-35 pulse Doxycycline have reliable effectiveness in the treatment of late- onset female patients with Acne Vulgaris.