1例抗磷脂综合征合并肺动脉高压的治疗和药学监护

1例27岁女性，因出现快走时喘息、胸痛入院，诊断为肺动脉高压、抗磷脂综合征。给予安立生坦片、他达拉非片、曲前列尼尔注射液、华法林片等降肺动脉高压、抗凝治疗。临床药师综合患者病情、联合用药、体重等，估计华法林的剂量。个体化调整肺动脉高压靶向药物，对曲前列尼尔不良反应进行监护。经过对症治疗，患者病情好转出院。

Clinical Pharmacists Participate in the Treatment and Pharmaceutical Care of a Patient with Antiphospholipid Syndrome Complicated with Pulmonary Hypertension

A 27-year-old female presented with wheezing and chest pain during fast walking and was diagnosed with pulmonary hypertension and antiphospholipid syndrome. After admission, bosentan tablets, tadalafil tablets, treprostol injection, warfarin tablets and other treatments for descending pulmonary hypertension and anticoagulation were given. The patient''s condition was complex. Clinical pharmacists estimated the dose of warfarin based on the patient''s condition, combination of drugs, body weight, etc. Clinical pharmacists also performed individualized adjustment of targeting drugs for pulmonary hypertension and monitoring of traprostol adverse reactions. After symptomatic treatment, the patient''s condition improved and was discharged.