| 人参皂甙对培养大鼠皮层神经细胞O_2~-和H_2_O_2损伤的保护作用 |
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| 引用本文： | 李天威,孔乐凯,熊文,杨翰仪. 人参皂甙对培养大鼠皮层神经细胞O_2~-和H_2_O_2损伤的保护作用[J]. 吉林大学学报(医学版), 1998, 0(2) |
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| 作者姓名： | 李天威 孔乐凯 熊文 杨翰仪 |
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| 作者单位： | 白求恩医大基础医学院生物化学教研室(李天威，熊文，杨翰仪)，山东医科大学病生教研室(孔乐凯) |
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| 摘 要： | 目的：研究人参皂甙对培养大鼠皮层神经细胞自由基损伤的保护作用。方法：应用O-2和H2O2对培养大鼠皮层神经细胞损伤模型。结果：与损伤组比较，人参皂甙保护组的乳酸脱氢酶（LDH）释放量显著减少（P<0．01）；而细胞存活率显著增高（P＜0．01）。结论：人参皂甙能保护培养大鼠皮层神经细胞少受自由基损伤。
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| 关 键 词： | 人参皂甙 神经细胞培养 自由基 |
Protection of ginsenosides against O_2~- and H_2O_2 damage to cultured rat cortical neuronal cells |
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| Li Tianwei,Kong Lekai,Xiong Wen,et al. Protection of ginsenosides against O_2~- and H_2O_2 damage to cultured rat cortical neuronal cells[J]. Journal of Jilin University: Med Ed, 1998, 0(2) |
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| Authors: | Li Tianwei Kong Lekai Xiong Wen et al |
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| Affiliation: | Department of Biochemistry of Norman Bethime University of Medical Sciences Department of Pathophysilolgy of Shandong Medical University |
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| Abstract: | Objective: To study the protection of ginsenosides against the free radical damage to cultured rate conical neuronal cells. Methods: The model of O-2 and H2O2 damage to cultured rat cortical neuronal cells was used. Results:Compared with the damaged group,the lactate dehydrogenase (LDH) release decreased significantly (P<0. 01) and the neuronal survival rate increased significantly (P<0. 01 ) in the protective group of ginsenosides. Conclusion:Ginsenosides can protect the cultured rat conical neuronal cells from free radical damage. |
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| Keywords: | ginsenoside cortical cultures free radicals |
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