纳洛酮治疗早产儿呼吸暂停

目的 探讨纳洛酮对早产儿呼吸暂停的临床疗效.方法 64例早产儿呼吸暂停患儿随机分为治疗组和对照组,治疗组在常规治疗的基础上加用纳洛酮,首次剂量为0.1 mg·kg-1静推,后用0.1 mg·kg-1加入5%(或10%)葡萄糖液20～40 ml中,输液泵泵入,4 h内泵完,使纳洛酮维持在0.05～0.1 ml·h-1,每8 h重复一次;对照组在常规治疗基础上加用氨茶碱,首次剂量为5 mg·kg-1,12 h后给维持量2 mg·kg-1,每12 h静点一次,维持3～5 d.结果 治疗组总有效率稍高于对照组,两者相比无显著性差异.结论 纳洛酮应用治疗早产儿呼吸暂停疗效确切.

Clinical Effect of Naloxone on Premature Infants with Primary Apnea

Objective To observe the clinical benefits of naloxone on premature infants in primary apnea.Methods 64 premature infants with primary apnea were divided into two groups,the treatment group and the control group.Infants in the treatment group by 0.1 mg/kg with 0.005-0.01 mg/kg.h pumped constantly into intravenous for 4 hours,repeated every 8 hours.Infants in the control were added aminophyline with initial dose 5 mg/kg,fo11owed by 2 mg/kg after 12 hours,repeated every 12 hours for 3-5 days.Results The total effective rate in treatment group was higher than that in control group,but there was no difference between the two groups.Conclusion Naloxone in treating primary apnea of premature infants is effective.