|
|||||
|
|
| 挤压伤后丙二醛和一氧化氮的变化 | |
| 引用本文： | 王立金,汪思应,方玉荣. 挤压伤后丙二醛和一氧化氮的变化[J]. 中国基层医药, 2002, 9(6): 531-532 |
| 作者姓名： | 王立金 汪思应 方玉荣 |
| 作者单位： | 1. 安徽理工大学医学院,淮南,232001 2. 安徽医科大学病理生理教研室 3. 安徽理工大学医学院 |
| 摘 要： | 目的 观察挤压伤后脂质过氧化物的终产物－丙二醛（MDA）和一氧化氮（NO）含量变化。方法 复制挤压伤的大鼠模型，测定正常和挤压伤后平均动脉压（MAP）和血浆MDA、NO的含量变化，检测解压2h后心、肝、肾、小肠组织的MDA和NO含量。结果 解压后挤压伤组MAP值均低于对照组，血浆和组织中MDA、NO均高于对照组，并有统计学意义。结论 挤压伤后组织器官损伤与缺血再灌注有关，氧自由基和一氧化氮产生增多是其重要的机制。 |
| 关 键 词： | 挤压伤 丙二醛 一氧化氮 大鼠 缺血再灌注 自由基 |
| 修稿时间： | 2002-04-28 |
The alteration of lipid peroxidation and nitric oxide after cursh injury in rats |
|
| WANG Lijin,WANG Siying,FANG Yurong.Medical College,Anhui Science and Engineering University,Huainan. The alteration of lipid peroxidation and nitric oxide after cursh injury in rats[J]. Chinese Journal of Primary Medicine and Pharmacy, 2002, 9(6): 531-532 | |
| Authors: | WANG Lijin WANG Siying FANG Yurong.Medical College Anhui Science Engineering University Huainan |
| Affiliation: | WANG Lijin,WANG Siying,FANG Yurong.Medical College,Anhui Science and Engineering University,Huainan,232001 |
| Abstract: | Objective To alter of the lipid peroxidation and the nitricoxid after crush injury in rats.Methods The hindlimbs of rats were crushed by 20kg weight 5 hours,then measure the mean arterial presure(MAP),and to detecte the value of MDA,NO in plasma,myocardium,liver,lung,kidney,intestine.Results MAP in injure group were lower then in normal group;MDA,NO contents in plasma,heart,liver,lung,kidey,intestine were increased obviously in injure group.There were significant difference in two groups.Conclusion These results indicate that lipid peroxidation and nitric oxide may be one of the mechanisms in reperfusion injury after crush injury. |
| Keywords: | Crush injury MDA Nitric oxide Rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |