诊断-偏最小二乘法同时测定去痛片中各组分含量

去痛片中４个组分光谱行为间存在较强的相互干扰作用，从而使其光谱线性加和性较差．本文首先采用诊断方法剔除非线性点．然后再用偏最小二乘法处理数据，较之单用偏最小二乘法取得了更加满意的结果．用本法对去痛片进行了８个模拟样品的计算．非那西丁、咖啡因、苯巴比妥、氨基比林的平均回收率分别为１００４％，１００３％，９９５％和１００４％，ＲＳＤ分别为０９０％，１９％，１８％，１６％（ｎ＝６）．并与地方标准法（天津 ７４）结果进行了比较，经ｔ检验（α＝００５）表明，两者结果无显著性差异．

Simultaneous Determination of the Content of Each Component in QU-TONG Tablets by Diagnostic Partial Least Squares

Four components of Qu Tong tablets interact on each other in the solution strongly.So,their linear additivity of UV spectroscopy is poor.In this paper,we used firstly the diagnostic method to reject nonlinear points and then partial least squares to process the data.The results were better than those of using partial least squares alone.We used this method to calculate eight simulate samples.The mean recovery of phenacetin,caffeine,phenobabital and aminophenazone were 100 4%,100 3%,99 5%,and 100 4% respectively. RSD were 0 9%,1 8%and 1 6% resectively.These results were compared with those of the standard method(Tianjin 74).The t test(α 0 05)showed that the results of the two methods had no significant difference.