鱼牡蛎生乳灵胶囊促进大鼠泌乳功能的实验研究

目的： 观察鱼牡蛎生乳灵胶囊(简称生乳灵胶囊)促进大鼠泌乳功能的作用。方法：SD大鼠采用超负荷哺乳模型，设生乳灵胶囊1 800、900、450 mg/kg组和空白对照组，在哺乳期连续灌胃给予受试物25 d，观察哺乳期母鼠体质量、仔鼠体质量、仔鼠存活率和母鼠乳腺组织病理学检查等指标。结果：生乳灵胶囊各剂量组母鼠体质量未见明显异常；450、900 mg/kg组仔鼠生存率在89%~94%，仔鼠窝平均体质量与对照组相比有一定增长，但差异均无统计学意义(P>0.05)；而1 800 mg/kg组仔鼠生存率为100%，仔鼠窝平均体质量在哺乳早期(出生后0～8 d)和晚期(出生后17～25 d)出现明显增长(P<0.05)，乳腺组织内乳汁较多、腺泡腔充盈、乳腺管扩张明显。结论：生乳灵胶囊在相当于人用量10倍(1 800 mg/kg)时，可以促进哺乳期大鼠的乳汁分泌，增加仔鼠的体质量，减少仔鼠营养不良性死亡。

Function of Yu-mu-li-sheng-ru-ling capsule in facilitating milk secretion in rats

To study the function of Yu-mu-li-sheng-ru-ling capsule in milk secretion in rats. METHODS：SD rats with overload lactation model were used. The pregnant rats were randomly divided into four groups,including test groups with different dosage （1 800,900,450 mg/kg） and negative control group. The mother rats were gavaged for 25 d continuously during lactation. Body weight of mother and baby rats,survival ratio of baby rats and breast tissue pathology examination of mother rats were evaluated. RESULTS：No significant differences were observed in body weight of treated mother rats. For 450 and 900 mg/kg groups,baby rat survival ratios were 89%-94%, average body weight was insignificantly increased compared with that in negative control group（P〉0.05）. For 1 800 mg/kg group,baby rat survival ratio was 100%,average body weight increased significantly during early and late stage of lactation （P〈0.05）. Increased milk in breast tissue,filled acinus cavities and expanded mammary gland tubes were obviously observed. CONCLUSION：At 10 times higher than clinical dosage （1 800 mg/kg）,Sheng-ru-ling capsule could facilitate milk secretion in lactating rats,increase baby rat body weight and reduce malnutrition death.