心踝血管指数与高同型半胱氨酸血症的相关性研究

目的探讨血管性疾病患者心踝血管指数（CAVI）与高同型半胱氨酸血症（HHcv）之间的相关性。方法选择高血压、冠心病患者63例，根据血浆同型半胱氨酸（Hcy）水平分为对照组（35例）及HHcv组（28例）。应用动脉僵硬度自动检测装置测定CAVI作为反映动脉僵硬度的指标。结果HHcy组CAVI、颈一股脉搏波传导速度（CFP．WV）显著高于对照组（9．59±2．47VS．7．77＋1．86，P=0．002；13．54＋3．28VS．10．63_＋2．65，P〈0．001）。63例患者中血浆Hey与年龄、CFPWV、CAVl分别呈正相关（r分别为0．357，0．331，0．417；P均〈0．05）。校正年龄、性别因素后，Hcv与CFPWV、CAVI仍呈正相关（r=0．260及0-316．P均〈0．05）。多元线性回归分析显示Hcv是CAVI的独立影响因素（β=0．447，P=0．013）。结论HHcv患者CAVI水平显著升高，提示Hcv参与了动脉僵硬度的发生进展过程。

Possible link between cardio-ankle vascular index and homocysteine in patients with vascular related diseases

Objective To investigate the possible link between cardio-ankle vascular index and homocysteine （Hcy） level in vascular related diseases. Methods Sixty-three patients （M/F： 30/33, age： 64.6_＋13.7ys） with hypertension or coronary artery disease （CAD） from Peking University Shougang Hospital Vascular Medicine were enrolled into our study. They were divided into two groups： the control group （n=35）, and the hyperhomocysteinemia （HHcy） group （n=28）. The VS-1000 was used to measure CAVI. Carotid-femoral pulse wave velocity （CFPWV） was detected by the Complior apparatus. Results The value of CAVI, CFPWV were higher in the HHcy group than in the control group （9.59_＋2.47 vs. 7.77_＋1.86, P = 0.002; 13.54_＋3.28 vs. 10.63_＋2.65, P 〈 0,001）. However, the prevalence of hypertension or CAD was not significantly different between these two groups. Hcy was positively correlated with age, CFPWV, CAVI in the entire study group （r = 0.357,r = 0.331 ,r = 0.417, all P 〈 0.05） even after adjusting for age and gender. Multivariate analysis showed that Hcy was an independent associating factor of CAVI in all subjects （β = 0.447, P = 0,013）. Conclusion CAVI is significantly higher in hyperhomocysteinemia patients indicating that Hcy may play a role in the development of arterial stiffness.