COX-2、MMP-9在胃癌中的表达及意义

目的：研究胃癌组织中COX-2、MMP-9的表达的临床意义以及二者的相互关系。方法应用免疫组织化学方法检测收集的52例胃癌标本中COX-2、MMP-9蛋白的表达，并将检测结果进行分析。结果52例胃癌组织中COX-2、MMP-9蛋白的阳性表达率分别为78％和70％，而在胃正常组织中均呈低表达或不表达，两者有显著性差异（P＜0.05）。 COX-2、MMP-9蛋白在不同浸润深度、TNM分期及淋巴结转移组中的表达有显著差异，而在不同分化程度、年龄中无显著差异（ P＞0.05）；COX-2的表达与MMP-9的表达显著相关（P＜0.05，r＝0.3587）。结论 COX-2可诱导MMP-9的表达，并在促进胃癌的侵袭转移中发挥重要作用。

The significance of COX-2, MMP-9 expression in gastric carcinoma

Objective To investigate the expression and clinical significance of COX-2 and MMP-9 in gastric carcinoma and the re-lationship between COX-2 and MMP-9.Methods Immunohistochemistry test were performed to detect the expression of cases of gastric cancer for COX-2 and MMP-9 protein, and then analysis the results .Results The positive rates of COX-2, MMP-9 expression in 52 cases of gastric cancer were 78%and 70%respectively,whereas in normal tissue were rare （P＆gt;0.05）.The expression of cases of gas-tric cancer for COX-2 and MMP-9 protein were significant differences in different depth of the tumor invasion ,TNM phage and lymph node metastasis,but no difference in gende, differentiation （P＆gt;0.05）.There were significant positive correlation between COX-2 and MMP-9（P＆lt;0.05,r=0.3587）.Conclusion These data suggest that the expression of COX-2 can regulate the expression of MMP-9 and both of them play an important role in metastasis of gastric carcinoma .