An Unusual Case of Multiple Gastric Carcinoids Associated with Diffuse Endocrine Cell Hyperplasia and Parietal Cell Hypertrophy |
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Authors: | Ooi Akishi Ota Masako Katsuda Shogo Nakanishi Isao Sugawara Hiroyuki Takahashi Ichiro |
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Institution: | (1) Division of Pathology, Komatsu City General Hospital, Komatsu, Japan;(2) Division of Surgery, Komatsu City General Hospital, Komatsu, Japan;(3) Department of Pathology, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920 Kanazawa, Ishikawa, Japan |
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Abstract: | We describe a case of multiple gastric carcinoid tumors in a 47-year-old Japanese man. The patient had markedly elevated serum
gastrin levels (>800 pg/mL), which were suppressed by secretin-pancreozymin administration. In the partial gastrectomy specimen,
a total of 19 carcinoids arose from diffuse linear and micronodular hyperplasia of the oxyntic mucosal endocrine cells. The
carcinoid cells were chromogranin A-positive. Except for a very small number of serotonin-positive cells in several carcinoids,
none of the 19 reacted with a battery of antibodies to other bioactive neuroendocrine substances. The most prominent findings
in this case were peculiar fundic glands that were distended with a proteinaceous substance and lined with large hypertrophic
parietal cells. At the ultrastructural level, these cells showed poorly developed intracytoplasmic canaliculi and vesicotubular
profiles, yet their large cytoplasm had numerous mitochondria. On the basis of our histological and ultrastructural findings
we suggest that an intrinsic HCl secretion abnormality of the parietal cells may be responsible for the patient's hypergastrinemia.
Since there have been no reports on similar parietal cells changes, it is possible that our case may represent a pathological
entity not previously described. |
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Keywords: | Multiple gastric carcinoid endocrine cell hyperplasia parietal cell hypertrophy |
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