| 血清抗果蝇唾腺染色体抗体测定及临床意义探讨 |
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| 引用本文： | 丁玉珍,肖玉兰.血清抗果蝇唾腺染色体抗体测定及临床意义探讨[J].中国免疫学杂志,1990,6(3):170-172. |
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| 作者姓名： | 丁玉珍 肖玉兰 |
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| 作者单位： | 解放军总医院风湿科，解放军总医院风湿科，解放军总医院风湿科 北京 100853，北京 100853，北京 100853 |
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| 摘 要： | 以果蝇唾腺作为基质,用间接免疫荧光法检测血清抗果蝇唾腺染色体抗体简称抗染色体抗体(Anti—chromosome antibody AchrA)]。正常人及其它风湿性疾病患者共151例,均为阴性,而系统性红斑狼疮(SLE)患者44例,AchrA阳性者占16例(36.4%)。揭示AchrA对SLE有高度特异性及一定的敏感性。对比SLE患者的AchrA及抗核抗体(ANA),双阳性占15例(34.1%),提示与两种抗体起反应的核成分不尽相同。
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| 关 键 词： | 唾腺 染色体 抗体测定 果蝇 |
Measurement of serum anti-polytene chromosome of Drosophila melanogaster antibody and its clinical significance |
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| Ding Yuzhen,et al Division of Rheumatology,Chinese PLA General hospital,Beijing.Measurement of serum anti-polytene chromosome of Drosophila melanogaster antibody and its clinical significance[J].Chinese Journal of Immunology,1990,6(3):170-172. |
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| Authors: | Ding Yuzhen Division of Rheumatology Chinese PLA General hospital Beijing |
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| Institution: | Ding Yuzhen,et al Division of Rheumatology,Chinese PLA General hospital,Beijing 100853 |
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| Abstract: | During the period of 1986-1988, serum anti-polytene chromosome of Drosophila melanogaster antibody (AChrA) was measured by indirect immunofluorescence assay (IIF). One hundred and ninetyfive sera obtained from normal individuals and patients with systemic lupus erythematosus(SLE) and other rheumatic diseases (ORDs) were analysed. The results showed that 16 of the 44 patients with SLE tested were AchrA positive (36. 4%) whereas 42 normal individuals and 109 ORDs were all negative. The results suggest that AChrA is more specific than anti-nuclear antibody in SLE and may provide a new aid for diagnosing SLE. |
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| Keywords: | Polytene chromosome of Drosophila Anti-chromosome antibody Systemic lupus erythematosus |
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