移植后补充戊酸雌二醇对IVF-ET妊娠结局的影响

目的：探讨胚胎移植后黄体期不同剂量戊酸雌二醇对体外受精-胚胎移植（IVF-ET）妊娠结局的影响．方法选取2011年2月至2012年10月在昆明医科大学第二附属医院生殖医学科接受IVF-ET的患者362例，随机分为3组，用标准长方案进行控制性超促排卵，均自取卵日后行黄体酮肌注60 mg/d．A组为对照组，112例，不加用戊酸雌二醇；B组为实验组1，122例，在移植后加用戊酸雌二醇4 mg/d；C组为实验组2，128例在移植后加用戊酸雌二醇6 mg/d；比较各组妊娠结局．结果 A组和B组的胚胎种植率和妊娠率差异无统计学意义（＞0.05）；B组和C组的胚胎种植率和妊娠率差异无统计学意义（＞0.05）；A组和C组的胚胎种植率和妊娠率差异有统计学意义（＜0.05）．结论6 mg/d补戊酸雌二醇用于黄体支持有可能提高IVF后的种植率和妊娠率．

The Influence of Pregnancy Outcomes with Estradiol Valerate in Addition during Luteal Phase in IVF- ET Cycles

Objective To evaluate the influence of pregnancy outcomes with different dosage of estradiol valerate in addition to progesterone for luteal supplementation in IVF-ET cycles. Methods From February 2011 to October 2012, 362 patients undergoing IVF-ET in the second affiliated hospital of Kunming Medical University were selected. The patients were randomly assigned into three groups. Since oocyte retrieval, all of them were injected luteal supplementation with progesterone in oil 60 mg/d, im. Group A as control group （112 cases） did not add with pentanoic acid estradiol;Group B for the experimental group （122 cases）, added pentanoic acid estradiol 4 mg/d after embryo transfer;Group C for the experimental group （128 cases） added pentanoic acid estradiol 6 mg/d after embryo transfer. Finally the pregnancy outcome and implantation rate were compared for each group. Results There were no significant differences between group A and group B, group B and group C in the rate of embryos grow and pregnancy rate （ 〉0.05） . The embryo planting rate and pregnancy rate have significant difference between Group A and group C （ 〈 0.05） . Conclusion 6 mg/d fill estradiol valerate for luteal supplementation may improve implantation rate and pregnancy rate after IVF.