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Multisystem inflammatory syndrome in children associated with SARS-CoV-2 in a solid organ transplant recipient |
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| Authors: | Leanne M. Petters Tiphanie P. Vogel Flor M. Munoz Jose A. Hernandez Sarah Koohmaraie Michael J. Nowicki Caleb E. Zumbro Krupa R. Mysore |
| Affiliation: | 1. Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas;2. Texas Children’s Hospital, Houston, Texas Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas;3. Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas Texas Children’s Hospital, Houston, Texas;4. Texas Children’s Hospital, Houston, Texas Section of Pediatric Interventional Radiology, Department of Radiology, Baylor College of Medicine, Houston, Texas;5. Texas Children’s Hospital, Houston, Texas;6. Department of Pediatrics, The University of Mississippi Medical Center, Jackson, Mississippi;7. Department of Pediatrics, The University of Mississippi Medical Center, Jackson, Mississippi Department of Medicine, The University of Mississippi Medical Center, Jackson, Mississippi;8. Texas Children’s Hospital, Houston, Texas Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas |
| Abstract: | We present the case of a 3-year-old female liver transplant recipient with a history of Caroli disease who presented with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) test and was ultimately diagnosed with multisystem inflammatory syndrome in children (MIS-C) complicated by portal vein thrombosis. To the best of our knowledge, this is the first case report of MIS-C in a pediatric solid organ transplant (SOT) recipient. Based on our patient, MIS-C could be a potential complication of Coronavirus disease 2019 (COVID-19) in SOT recipients and may have a negative outcome on transplant graft function. |
| Keywords: | clinical research/practice complication infection and infectious agents - viral infectious disease liver transplantation/hepatology pediatrics |