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Suppression of amiodarone-induced torsade de pointes by landiolol in a patient with atrial fibrillation-mediated cardiomyopathy |
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| Authors: | Koji Takahashi MD Mina Yamashita MD Tomoki Sakaue MD Daijiro Enomoto MD Shigeki Uemura MD Takafumi Okura MD Shuntaro Ikeda MD Masafumi Takemoto ME Yutaka Utsunomiya ME Takashi Hyodo ME |
| Affiliation: | 1. Department of Community Emergency Medicine, Ehime University Graduate School of Medicine, Ehime, Japan;2. Department of Cardiology, Yawatahama City General Hospital, Ehime, Japan;3. Department of Community Emergency Medicine, Ehime University Graduate School of Medicine, Ehime, Japan Department of Cardiology, Yawatahama City General Hospital, Ehime, Japan;4. Department of Medical Engineering, Yawatahama City General Hospital, Ehime, Japan |
| Abstract: | An elderly Japanese woman developed acute decompensated heart failure caused by persistent atrial fibrillation (AF) and left ventricular systolic dysfunction. Approximately 6 days after starting intravenous administration of amiodarone (600 mg/day) for maintaining sinus rhythm after cardioversion of AF, electrocardiograms revealed a prolonged QT interval associated with torsade de pointes (TdP). The amiodarone-induced TdP disappeared after intravenous administration of landiolol plus magnesium and potassium, without discontinuation of amiodarone or overdrive cardiac pacing, although the prolonged QT interval persisted. To the best of our knowledge, this is the first report that landiolol could be effective for amiodarone-induced TdP. |
| Keywords: | amiodarone atrial fibrillation heart failure landiolol long QT syndrome torsade de pointes |