|
|||||
|
|
An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients |
|
| Authors: | Vinay Nair Nicholas Jandovitz Jamie S Hirsch Mersema Abate Sanjaya K Satapathy Nitzan Roth Santiago J Miyara Sara Guevara Adam M Kressel Alec Xiang Grace Wu Samuel D Butensky David Lin Stephanie Williams Madhu C Bhaskaran David T Majure Elliot Grodstein Lawrence Lau Gayatri Nair Ahmed E Fahmy Aaron Winnick Nadine Breslin Ilan Berlinrut Christine Molmenti Lance B Becker Prashant Malhotra Pranisha Gautam-Goyal Brian Lima Simon Maybaum Samit K Shah Ryosuke Takegawa Kei Hayashida Koichiro Shinozaki Lewis W Teperman Ernesto P Molmenti Northwell Health COVID- Research Consortium |
| Institution: | 1. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York;2. North Shore University Hospital, Northwell Health, Manhasset, New York;3. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York
Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York Department of Information Services, Northwell Health, New Hyde Park, New York;4. Department of Surgery, Northwell Health, Manhasset, New York;5. North Shore University Hospital, Northwell Health, Manhasset, New York Department of Surgery, Northwell Health, Manhasset, New York;6. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York North Shore University Hospital, Northwell Health, Manhasset, New York;7. North Shore University Hospital, Northwell Health, Manhasset, New York Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York;8. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York Department of Surgery, Northwell Health, Manhasset, New York;9. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York;10. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York North Shore University Hospital, Northwell Health, Manhasset, New York Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York;11. Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York;12. North Shore University Hospital, Northwell Health, Manhasset, New York Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York |
| Abstract: | We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio OR] 1.29; 95% CI 0.99–1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03–1.74, p = .027). |
| Keywords: | clinical research/practice immunosuppression/immune modulation infection and infectious agents - viral infectious disease kidney (allograft) function/ dysfunction organ transplantation in general |