Involvement of monoaminergic system in the antidepressant‐like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice |
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Authors: | Francisca Cléa Florenço de Sousa Iris Cristina Maia Oliveira Maria Izabel Gomes Silva Carla Thiciane Vasconcelos de Melo Vívian Romero Santiago Raquell de Castro Chaves Mariana Lima Fernandes Stanley Juan Chaves Gutierrez Silvânia Maria Mendes Vasconcelos Danielle Silveira Macêdo José Maria Barbosa Filho |
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Institution: | 1. Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, , 60430‐270 Fortaleza‐Ceará, Brazil;2. Laboratory of Pharmaceutics Technology, Federal University of Paraíba, , Jo?o Pessoa‐Paraíba, Brazil |
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Abstract: | In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant‐like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for antidepressant activity in rodents. In addition, the involvement of the monoaminergic system in this effect was also assessed. rip I was acutely administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that rip I at both tested doses and administration routes produced a significant decrease in immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1‐adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α2‐adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p‐chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis) or ritanserin (4 mg/kg, a serotonin 5‐HT2a/2c receptor antagonist) blocked the anti‐immobility effects elicited by rip I (50 mg/kg, p.o.) in the FST. Taken together, results indicate that rip I produces significant antidepressant‐like activity in the FST and TST, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic and serotonergic systems. |
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Keywords: | Aniba riparia antidepressant‐like effect dopaminergic system noradrenergic system riparin I serotonergic system |
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