荣肝饮抗肝纤维化作用的实验研究 |
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引用本文: | 张永,韩宁.荣肝饮抗肝纤维化作用的实验研究[J].山东中医药大学学报,1998,22(4):309-310. |
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作者姓名: | 张永 韩宁 |
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作者单位: | 山东中医药大学附属医院 |
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摘 要: | 以CC14等因素复制大鼠肝纤维化模型,以血清丙氨酸氨基转移酶(ALT)水平,血清层粘连蛋白(LN)、透明质酸(HA)含量,光、电镜下肝组织改变为观察内容,观察荣肝饮的治疗作用,设正常组和模型组作为对照。结果表明,荣肝饮能显著降低血清ALT水平及血清LN、HA含量,明显改善肝组织炎症状态,与模型组比较,P<0.01。表明荣肝饮有一定的抗肝纤维化的作用,主要体现在促纤维组织降解方面
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关 键 词: | 荣肝饮 肝纤维化 血清丙氨酸氨基转移酶 血清层粘连蛋白 血清透明质酸 肝组织结构 大鼠 |
The Experimental Study of Ronggan Decoction on Anti-liver Fibrosis |
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Abstract: | We duplicated the animal pattern of the liver fibrosis by injecting CCl_4 suspension to white Mice's abbominal cavity,and take the content of ALT、HA、LN in blood serums and the change of the hepatic tissue under the optical and the electron microscope.After 4 weeks treatment with Rongan decoction,compared with the control group,the liver function and the serum parameters of fibrosis were significantly decreased(p<0.01)。The results show that Ronggan decoction has the effect of antifibrosis,and the further improved study is needed. |
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Keywords: | Ronggan decoction Liver fibrosis ALT Laminin HyaluronicacidHepatic tissue White Mice |
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