果糖氯化钠注射液在急危重病救治中的临床研究

目的观察果糖氯化钠注射液在急危重病救治中对机体内环境的影响。方法将120例急危重病患者随机分为试验组（60例）和对照组（60例），开放静脉通道的第一瓶液体分别使用果糖氯化钠注射液250ml及0．9％氯化钠注射液250ml，输液速度均为10ml／min。观察两组患者治疗前后的血钾、血钠、血氯、血糖水平变化。结果试验组治疗前后血钾、血钠、血氯、血糖水平变化绝对值分别为（0．26±0．25）mmol/L、（1．7±1．7）mmol／L、（1．5±1．3）mmol／L和（0．7±0．5）mmoL／L，对照组分别为（0．32±0．40）mmol／L、（2．7±3．1）mmol／L、（2．4±2．8）mmol／L和（0．7±0．5）mmol／L，两组患者治疗前后血钠、血氯水平变化绝对值间差异有统计学意义（P〈0．05），而血钾、血糖水平变化绝对值间差异无统计学意义（P〉0．05）。结论果糖氯化钠注射液可以保持血钾及血糖水平稳定，且血钠、血氯变化值小于0．9％氯化钠注射液，可为急危重患者提供能量而不引起血糖、血钾升高，是一种安全、合适的注射液。

Clinical Study of Fructose and Sodium Chloride Injection for Treatment of Critical Illness

Objective To observe the effect of fructose and sodium chloride injection on in vivo environment in treatment of critical illness. Methods One hundred twenty critically sick patients were divided randomly into groups experiment (n = 60) and control (n =60). Experimental group first used fructose and sodium chloride injection, 250 ml, lOml/min, and control group 0. 9% sodium chloride injection, 250 ml, 10 ml/min. Serum potassium, sodium, chloride, blood glucose were observed before treatment and after. Results The levels of serum potassium, sodium, chloride, blood glucose in absolute value were (0. 26 ±0. 25) mmol/L, (1.7 ±1.7) mmol/L, (1.5 ±1.3) mmol/L, (0.7±0.5) mmol/L, respectively, in experimental group, and (0.32 ±0.40) mmol/L, (2. 7 ±3.1) mmol/L, (2. 4 ±2. 8) mmol/L and (0. 7 ±0. 5) mmol/L, respectively, in control. There was significant difference in levels of serum sodium, chlorine in absolute value between 2 groups before treatment and after ( P < 0. 05) , but not in serum potassium and blood glucose level (P > 0. 05 ). Conclusion Fructose and sodium chloride injection can maintain the stability of levels of serum potassium and blood glucose. The changes of serum sodium and chloride were less in using fructose and sodium chloride injection than in using 0. 9% sodium chloride. It can provide energy for critically sick patients without causing blood glucose and serum potassium to rise, and is a safe and suitable injection.