阿立哌唑治疗首发精神分裂症对照研究

目的：对比阿立哌唑与奎硫平治疗首发精神分裂症的疗效和安全性。方法：分别以阿立哌唑与奎硫平治疗首发精神分裂症各60例，采用阳性症状和阴性症状量表（PANSS）、副反应量表（TESS），在治疗前及治疗后第1、2、4、6、8周末分别评定疗效及不良反应。结果：阿立哌唑有效率93．30％，显效率81．7％。奎硫平有效率96．7％，显效率83．3％，两组治疗后与治疗前PANSS评分比较差异有显著性，阿立哌唑不良反应少于奎硫平。结论：阿立哌唑治疗精神分裂症疗效较好，不良反应较奎硫平轻微，病人服药依从性良好。

A study of aripiprazole and in fhe treatment of firstonset schizophrenia

Objective:To compare the efficacy and safety between aripiprazole and quetiapine.Methods:sixty schizophrenic patients were treeted with aripirazole and another sixty patients treated with quetiapine.the efficacy was measured with the positive and negative symptoms scale(PANSS)Results: while the side effects were determined by efficacy rate of aripiprazole was 93.3%,in which 81.7%.were improved markedly,The efficacy rate of quetiapine was 96.7%,in which 83.3% were improved merkedly.the PANSS scores in both groups decreased significantly after treatment.aripirazole has less side effects than quetiaine.Conclusions: airpiprazole is of good efficacy,high safety and less side effects in treating schizophrenia,and patients and btter compliance.