妇科门诊21种人乳头状瘤病毒感染状况分析

目的：分析绍兴市区妇科门诊女性生殖道21种人乳头状瘤病毒（HPV）感染状况及其分布规律。方法：以2005年1月-2006年6月绍兴市区妇科门诊至少有1年以上性生活史的女性1359例为研究对象．采集其阴道宫颈分泌物标本，用凯普医用核酸分子杂交系统（简称HyrbriMax）进行21种HPV（6、11、16、18、31、33、35、39、42、43、44、45、51、52、53、56、58、59、66、68、CP8304）基因型的分型检测，分析常见感染亚型和分布规律。结果：研究人群HPV总阳性率为54．75％，常见的10种高危型为HPV16、52、58、68、18、31、33、66、CP8304、53：常见的3种低危型为HPV11、6、42。最常见高危型HPV16阳性率随年龄增加递增．最常见低危型HPV11的阳性率随年龄增加递减。多重感染的比例为44．35％，以二重感染最多见。结论：本地区妇科门诊HPV感染率和多重感染比例均较高，常见感染亚型既符合亚洲人群的分布规律，又有一定的区域性，值得重视。

Analysis of 21 genotypes of human papillomavirus infection in outpatient women

Objective：To study the 21 genotypes of human papillomavirus （HPV）infection and their distribution character in the female lower genital tract in outpatient women in Shao-xing city.Methods：A total of 1359 outpatient women who accepted cervical cancer screening in the main hospitals in Shao-xing city during Jun. 2005 to Jun.2006 were selected for 21 genotyps （6,11,16,18,31,33,35,39,42,43,44,45,51,52,53,56,58, 59,66,68,CP8304） HPV detecting with HybriMax.All the women had intercourse history of more than one year.Results：The total positive rate of HPV infection was 54.75%. The 10 most common high-risk genotypes were HPV16,52,58,68,18,31,33,66,CP8304,53.The 3 most common low-risk genotypes were HPV11,6,42. The positive rate of the most common high-risk type HPV16 increased with aging,while the positive rate of the most common low-risk type HPVll descended with aging.The total multiple infection rate was 44.35% and two types co-infection were the most common situation.Conclusion：The prevalence of HPV infection and multiple infection are common,the infection genotypes are accordant to those of asia,and also have its own character.