| 恩替卡韦治疗失代偿期乙型肝炎肝硬化 |
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| 引用本文： | 黄志刚,柳杰,许永萍. 恩替卡韦治疗失代偿期乙型肝炎肝硬化[J]. 传染病信息, 2009, 22(2): 112-114 |
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| 作者姓名： | 黄志刚 柳杰 许永萍 |
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| 作者单位： | 武警浙江总队医院,嘉兴,314000;武警浙江总队卫生处 杭州 310000 |
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| 摘 要： | 目的探讨恩替卡韦治疗失代偿期乙型肝炎（乙肝）肝硬化临床疗效。方法选取失代偿期乙肝肝硬化患者共44例。随机分为治疗组22例，对照组22例。2组均给予还原型谷胱甘肽、促肝细胞生长素、甘草酸二铵等综合性保肝、护肝治疗。对照组加拉米夫定100mg，口服，1／d；治疗组加恩替卡韦O．5mg，口服，1／d。疗程均为52周。结果2组患者在HBVDNA水平下降，改善肝功能、血清肝纤维化指标、凝血酶原活动度及Child-Pu-sh积分等方面与治疗前比较，有统计学意义；2组治疗后比较，无统计学意义。结论恩替卡韦治疗失代偿期乙肝肝硬化患者，疗效明确，安全洼好。
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| 关 键 词： | 恩替卡韦 拉米夫定 慢性乙型肝炎 失代偿期 乙型肝炎肝硬化 |
Entecavir therapy in patients with decompensated HBV-related cirrhosis |
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| Huang Zhigang,Liu Jie,Xu Yongping. Entecavir therapy in patients with decompensated HBV-related cirrhosis[J]. Infectious Disease Information, 2009, 22(2): 112-114 |
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| Authors: | Huang Zhigang Liu Jie Xu Yongping |
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| Affiliation: | Huang Zhigang,Liu Jie,Xu Yongping Zhejiang Armed Police Corps General Hospital,Jiaxing 314000,China |
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| Abstract: | Objective To evaluate the effect of entecavir on patients with decompensated hepatitis B virus(HBV)-related cirrhosis.Methods A total of 44 cases of decompensated HBV-related cirrhosis were randomly divided into a treatment group(n=22) and a control group(n=22).Based on a comprehensive liver-preventing treatment regimen,including reduced glutathione,hepatocyte growth factor and diammonium glycyrrhizinate in both groups,the patients in the treatment group were treated with entecavir(0.5 mg,1/d),while those i... |
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| Keywords: | entecavir lamivudine chronic hepatitis B decompensation hepatitis B virus(HBV)-related cirrhosis |
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