| 绵头雪莲花提取物对UVA照射后人成纤维细胞增殖的影响 |
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| 引用本文： | 郑博文,阮光洪,尼玛此里,鲁茸达瓦,瞿红叶,黄相中,李冰,陈文雄,夏玉洁,邓丹琪. 绵头雪莲花提取物对UVA照射后人成纤维细胞增殖的影响[J]. 中国麻风皮肤病杂志, 2017, 0(9): 531-535 |
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| 作者姓名： | 郑博文 阮光洪 尼玛此里 鲁茸达瓦 瞿红叶 黄相中 李冰 陈文雄 夏玉洁 邓丹琪 |
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| 作者单位： | 1. 云南省第二人民医院皮肤科,昆明医科大学第四附属医院皮肤科,云南昆明,650021;昆明医科大学第二附属医院皮肤科,650101;2. 云南省第二人民医院皮肤科,昆明医科大学第四附属医院皮肤科,云南昆明,650021;3. 德钦县人民医院藏医科,云南迪庆,674500;4. 云南省口腔医院口腔修复科,云南昆明,650101;5. 云南民族大学民族医药学院,民族药资源化学国家民委-教育部重点实验室,云南昆明,650504;6. 中国科学院昆明动物研究所,灵长类研究中心,昆明,650223;7. 昆明医科大学第二附属医院皮肤科,650101 |
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| 基金项目： | 云南省科技厅-昆明医科大学应用基础研究联合专项资金项目(2014FZ043) |
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| 摘 要： | 目的:明确绵头雪莲花提取物对UVA照射下的人成纤维细胞的保护作用。方法:制备绵头雪莲花浸膏,将培养的人成纤维细胞分为正常对照组、UVA照射组(10 J/cm~2)及UVA+药物组,CCK8法检测细胞增殖活性,并比较各组吸光度值。结果:UVA+药物组漂浮死细胞(低于5%)少于UVA照射组(约20%~30%);UVA+药物组(200μg/mL)吸光度值为1.16±0.22,高于UVA照射组的0.5±0.12,差异有统计学意义(P0.05)。结论:绵头雪莲花提取物对UVA照射人成纤维细胞具有一定的保护作用。
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| 关 键 词： | 绵头雪莲花 紫外线 UVA 人成纤维细胞 |
Effects of Saussurea laniceps on human fibroblasts proliferation affected by UVA irradiation |
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| ZHENG Bowen,RUAN Guanghong,NI Macili,LU Rongdawa,QU Hongye,HUANG Xiangzhong,LI Bing,CHENG Wenxiong,XIA Yujie,DENG Dangqi. Effects of Saussurea laniceps on human fibroblasts proliferation affected by UVA irradiation[J]. China Journal of Leprosy and Skin Diseases, 2017, 0(9): 531-535 |
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| Authors: | ZHENG Bowen RUAN Guanghong NI Macili LU Rongdawa QU Hongye HUANG Xiangzhong LI Bing CHENG Wenxiong XIA Yujie DENG Dangqi |
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| Abstract: | Objective:To determine the protective effects of the extract from Saussurea laniceps on the proliferation of human fibroblasts induced by UVA.Methods:The extract from Saussurea laniceps was prepared and the cultured human fibroblasts were divided into normal control group,UVA group and UVA+ Saussurea laniceps group.The cell proliferation activity was detected by CCK8 and the OD of cells was detected.Results:Dead cells in UVA+ Saussurea laniceps group were less than 5％,which was less than that in UVA group (20％～30％).OD in UVA+ Saussurea laniceps group was 1.16±0.22,which was higher than that in UVA group (0.5±0.12),with a significant difference (P<0.05).Conclusion:The extract of Saussurea laniceps has protective effects on human fibroblasts proliferation induced by UVA. |
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| Keywords: | saussurea laniceps ultraviolet UVA human fibroblasts |
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