苦参素联合抗组胺药治疗慢性荨麻疹疗效的Meta分析

目的:评价苦参素联合抗组胺药治疗慢性荨麻疹的疗效及不良反应。方法:检索中国知网、万方、维普、Pubmed、EMbase及Cochrane library等数据库,筛选符合标准的文献,采用RevM an 4.2进行Meta分析。结果:共纳入14篇文献,入选文献发表偏倚较小,无明显异质性(P=0.34)。Meta分析结果显示,苦参素联合抗组胺药组与单用抗组胺药组比较,有效率高[P0.00001,RR=1.40,95%CI(1.30~1.51)],复发率低[P0.00001,RR=0.19,95%CI(0.10-0.37)]。结论:苦参素联合抗组胺药治疗慢性荨麻疹疗效优于单用抗组胺药。

Meta-analysis of the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria

Objective:To assess the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria.Methods:The articles about the oxymatrine combined with antihistamines for treating chronic urticaria were searched in CNKI, WANGFANG database, VIP database, Pubmed, EMbase and Cochrane library.The Meta-analysis was performed by Review Manager 4.2 software.Results:A total of 14 researches were included, with small bias and no heterogeneous (P=0.25).The results of meta-analyses showed that compared with the group of antihistamines alone, the effective rate in the group of oxymatrine combined with antihistamines was higher (P<0.00001,RR=1.40, 95% CI(1.30~1.51)) and the recurrence rate was lower (P<0.00001, RR=0.19,95% CI(0.10-0.37)).Conclusion:Oxymatrine combined with antihistamines was more effective than antihistamines alone in the treatment of chronic urticaria.