| 乳腺癌循环肿瘤细胞与原发肿瘤临床病理特征关系的初步研究 |
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| 引用本文： | 齐晓伟,姜军,杨新华,范林军,张毅,张帆,陈莉,周艳.乳腺癌循环肿瘤细胞与原发肿瘤临床病理特征关系的初步研究[J].第三军医大学学报,2009,31(9). |
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| 作者姓名： | 齐晓伟 姜军 杨新华 范林军 张毅 张帆 陈莉 周艳 |
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| 作者单位： | 第三军医大学西南医院乳腺疾病中心,重庆,400038 |
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| 摘 要： | 目的 探讨乳腺癌循环肿瘤细胞(circulating tumor cell,CTC)与原发肿瘤临床病理特征的关系.方法 128例乳腺癌及30例乳腺纤维腺瘤患者首次住院时抽取静脉血5 ml,用密度梯度离心法富集分离单个核细胞,以免疫荧光法检测所获单个核细胞中细胞角蛋白(cytokeratin,CK)8/18阳性的CTC,分析CTC与患者临床病理特征的关系.结果 在128例乳腺癌患者中CTC阳性率为40.6%(52/128),30例乳腺纤维腺瘤患者均未检出CTC.不同淋巴结病理分期(pN0、pN1、pN2和pN3期)患者CTC阳性率分别为15.4%(6/39)、27.O%(10/37)、64.7%(11/17)和66.7%(12/18),各组CTC阳性率差异有统计学意义(P=0.000 6);转移性(M1期)乳腺癌患者CTC阳性率为80%(16/20),较非转移性(M0期)乳腺癌患者CTC总阳性率33.3%(36/108)显著升高(P=0.000 9);小同TNM分期(Ⅰ、Ⅱ、Ⅲ和Ⅳ期)患者CTC阳性率分别为12.5%(3/24)、32.0%(16/50)、50.0%(17/34)和80.0%(16/20),各组CTC阳性率差异有统计学意义(P=0.000 3).结论 部分乳腺癌患者血液中存在CTC.CTC与淋巴结转移、远处转移及TNM分期密切相关.检测CTC有利于进行更精确的病情评估.
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| 关 键 词： | 乳腺癌 循环肿瘤细胞 TNM分期 雌激素受体 孕激素受体 人表皮生长因子受体2 |
Circulating tumor cells and clinicopathologic characteristics of primary tumor of breast cancer patients:report of 128 cases |
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| QI Xiao-wei,JIANG Jun,YANG Xin-hua,FAN Lin-jun,ZHANG Yi,ZHANG Fan,CHEN Li,ZHOU Yan.Circulating tumor cells and clinicopathologic characteristics of primary tumor of breast cancer patients:report of 128 cases[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(9). |
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| Authors: | QI Xiao-wei JIANG Jun YANG Xin-hua FAN Lin-jun ZHANG Yi ZHANG Fan CHEN Li ZHOU Yan |
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| Institution: | QI Xiao-wei,JIANG Jun,YANG Xin-hua,FAN Lin-jun,ZHANG Yi,ZHANG Fan,CHEN Li,ZHOU Yan (Breast Disease Center,Southwest Hospital,Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To investigate the relationship between the presence of circulating tumor cells (CTCs) and the clinicopathologic characteristics of primary tumor of breast cancer patients. MethodsSamples of peripheral blood (5 ml) from 128 cases of patients with breast cancer and 30 cases of patients with breast fibroadenoma hospitalized for the first time were enriched by density gradient centrifugation for mononuclear cells, and then the cells were detected by immunofluorescence with anti-cytokeratin8/18 antibo... |
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| Keywords: | breast cancer circulating tumor cell TNM stage estrogen receptor progesterone receptor human epidermal growth factor receptor 2 |
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