健身宝对衰老模型小鼠血清SOD和MDA的影响

目的　研究健身宝补脾益肾、延缓衰老的作用机制。方法　将 60只小鼠随机分为 6组 ,除正常对照组外均每日注射对D -半乳糖造成衰老模型 ,同时给予不同剂量的健身宝和金匮肾气丸。 6周后检测小鼠血清中SOD活性、MDA含量。结果　衰老模型组与正常对照组比较 ,小鼠血清中SOD活性显著降低 ,MDA含量显著升高 (P <0 .0 1 ) ;而健身宝大、中剂量组与正常对照组相比较 ,小鼠血清中SOD活性显著升高 ,MDA含量显著降低 ,与衰老模型组相比较有显著性差异 (P <0 .0 5 )。结论　健身宝明显提升D -半乳糖拟衰小鼠血清中SOD活性 ,降低MDA含量 ,可从调节自由基代谢和提高抗氧化能力方面发挥延缓衰老的作用。

Effect of Jianshenbao on activity of SOD and content of MDA in serum of aged model mice

Objective It is to exploie the mechanism of Jianshenbao(JSB) on delaying seniling of aged mobel mice. Methods Sixty mice were randomly divided into six groups.They were treated with D galactose for aged model mice exceot control group,then they were treated with JSB and Jin Guishenqiwan.The activityof SOD and content of MDA in serum of sixty mice were determined and compared before and after treatment .Results The activity of SOD was lower and the content of MDA was higher in aged model group than that in control group( P <0.01). Compared with aged model group,the activities of SOD were higher and the content of MDA were significantly inhibited in JSB dose group,JSB low dows group and JSB high dose group( P <0.05).Conclusion JSB can increase SOD,inhibit MDA,and delay the senility.