Role of mitofusin 2 in cardiovascular oxidative injury |
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| Authors: | Ming Zheng Rui-Ping Xiao |
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| Institution: | (1) Institute of Molecular Medicine, Peking University, Beijing, 100871, People’s Republic of China;(2) Drug Discovery Center, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, People’s Republic of China; |
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| Abstract: | Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition
to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes,
including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential, and mtDNA stability. Dysfunction
of mitochondrial dynamics has been implicated in various human diseases, especially in neurodegenerative diseases. Emerging
evidence indicates that impaired expression of mitochondrial fusion proteins or their malfunction participates in oxidative
stress-induced cardiovascular injury. This review will focus on recent advances of mitochondrial fusion in regulating various
cellular processes in cardiovascular system. |
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