血小板源性生长因子BB与IgA肾病的关系

目的:探讨IgA肾病(IgA nephropathy,IgAN)患者血清中血小板源性生长因子BB(PDGF-BB)与肾脏不同病理改变的关系,旨在寻找一种能反映IgAN肾损害程度的非创伤性临床检测指标.方法:应用酶联免疫吸附法(ELISA)测定92例IgAN患者、30例微小病变性肾病(MCD)患者、30例健康对照的PDGF-BB水平并进行比较;将92例1gAN患者的肾脏病理按Lee氏分级分为A组(Lee氏Ⅰ级或Ⅱ级)16例,B组(Lee氏Ⅲ级)43例,C组(Lee氏Ⅳ级或Ⅴ级)33例,并进行katafuchi半定量评分,观察血清PDGF-BB水平与IgAN不同肾脏病理改变的关系.结果:(1) IgAN患者血清PDGF-BB的含量(746.530 t 293.012) ng/L明显高于MCD组(208.910±118.56)ng/L及正常对照组(215.320±124.064) ng/L(P＜0.05);MCD组(208.910±118.56) ng/L与正常对照组(215.320±124.064)ng/L对比无统计学意义(P＞0.05);(2)IgAN者中血清PDGF-BB的浓度C组(926.443±237.162)ng/L明显高于B组(693.103±284.608) ng/L及A组(519.043±198.671) ng/L(P <0.05);同时B组(693.103±284.608)ng/L高于A组(519.043±198.671) ng/L(P <0.05);(3) Pearson相关分析:血清PDGF-BB水平与平均动脉压、血肌酐,24h尿蛋白定量,尿素氮均呈正相关(r = 0.353,0.342,0.270,0.261; P均＜0.05);与肾小球滤过率呈负相关性(r=-0.414,P＜0.05);(4)多元线性回归分析:平均动脉压及Lee氏分级是血清PDGF-BB升高的独立危险因素.结论:血清PDGF-BB浓度可反映IgAN肾脏病理改变的严重程度,可做为IgAN肾损害的非创伤性临床检测指标.

Change of serum platelet derived growth gactor-BB(PDGF-BB) in patients with IgA nephropathy

Objective:To investigate the significance of serum platelet derived growth factor-BB(PDGF-BB)in different renal pathology injury of patients with IgA nephropathy.Methodology:Ninety two patients with IgAN,30 cases with minimal change disease(MCD) and 30 health adults were enrolled in this study.The serum PDGF-BB was measured by enzyme-linked immunosorbent assay(ELISA) in three groups' people.According pathological degree constituted by Lee's classifications,all patients with IgAN were divided into five degre...