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| 脂必泰胶囊中红曲的含量测定 | |
| 引用本文： | 温中明,张法,黄毅,谢静,罗江秀,魏照星,原文鹏. 脂必泰胶囊中红曲的含量测定[J]. 中国药业, 2011, 20(13): 21-23 |
| 作者姓名： | 温中明 张法 黄毅 谢静 罗江秀 魏照星 原文鹏 |
| 作者单位： | 1. 广东省深圳市光明新区公明人民医院药剂科,广东,深圳,518106 2. 广东省深圳市沙湾医院药剂科,广东深圳,518114 3. 广东省深圳市人民医院·暨南大学第二临床医学院药学部,广东,深圳,518020 |
| 基金项目： | 深圳市科技计划(医疗卫生类)项目;项目 |
| 摘 要： | 目的建立测定脂必泰胶囊红曲中洛伐他汀含量的高效液相色谱法。方法色谱柱为Dionex C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-水(75∶25),流速为1 mL/min,柱温为22℃,检测波长为236 nm,进样量为10μL。样品以75%乙醇超声提取10 min后进样测定,定量方法采用峰面积外标法。结果洛伐他汀质量浓度在0.011 83～0.473 2 g/L范围内与峰面积积分值线性关系良好(r=0.999 9),方法平均回收率为99.07%,RSD=1.77%(n=6)。结论该方法简单、快速、准确,适用于测定脂必泰胶囊红曲中洛伐他汀的含量。 |
| 关 键 词： | 脂必泰胶囊 红曲 洛伐他汀 含量测定 高效液相色谱法 |
Determination of Lovastatin in Zhibitai Capsules by HPLC |
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| Wen Zhongming,Zhang Fa,Huang Yi,Xie Jing,Luo Jiangxiu,Wei Zhaoxing,Yuan Wenpeng. Determination of Lovastatin in Zhibitai Capsules by HPLC[J]. China Pharmaceuticals, 2011, 20(13): 21-23 | |
| Authors: | Wen Zhongming Zhang Fa Huang Yi Xie Jing Luo Jiangxiu Wei Zhaoxing Yuan Wenpeng |
| Affiliation: | Wen Zhongming1,Zhang Fa2,Huang Yi3,Xie Jing3,Luo Jiangxiu1,Wei Zhaoxing1,Yuan Wenpeng3(1.The Gongming People's Hospital,Shenzhen,Guangdong,China 518106,2.Department of Pharmacy,Shawan People's Hospital,China 518114,3.Pharmacy Department of Shenzhen People's Hospital,Second Medical College of Ji'nan University,China 518020) |
| Abstract: | Objective To establish an HPLC method for the determination of lovastatin in Zhibitai Capsules.Methods A Dionex C18 column（250 mm×4.6 mm,5 μm）was used.The mobile phase was methanol-water（75 ∶25）with 1.0 mL/min of flow rate,the detective wavelength was 236 nm.External standard method was used.Results The standard curve of lovastatin was linear in the concentration of 0.011 83-0.473 2 g/L（r=0.999 9）,the average recovery rate was 99.07%,RSD=1.77%（n=6）.Conclusion The HPLC method was simple,rapid and accurate for the determination of lovastatin in Zhibitai Capsules. |
| Keywords: | Zhibitai Capsules Monascus Rice lovastatin content determination HPLC |
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