三七总皂苷注射液治疗脑梗死的多中心研究

目的 :探讨三七总皂苷治疗脑梗死的疗效。方法 :脑梗死病人 582例 ,随机分为 2组 ,三七总皂苷组 2 91例 (男性 199例 ,女性 92例 ,年龄 6 0a±s5a)。用三七总皂苷 4 0 0mg加入 5%葡萄糖或氯化钠注射液 50 0mL中静脉滴注 ,qd ;川芎嗪组 2 91例(男性 198例 ,女性 93例 ,年龄 59a± 7a)。用川芎嗪注射液 16 0mg加入 5%葡萄糖或氯化钠注射液50 0mL中静脉滴注 ,qd ,2组疗程均为 30d。结果 :三七总皂苷组总有效率 95 2 % ,不良反应少。川芎嗪组总有效率 82 1%。组间经Ridit分析 ,差别有显著意义 (P <0 .0 5)。结论 :三七总皂苷是一种安全有效治疗脑梗死的药物 ,较川芎嗪疗效显著

Panax notoginseng saporins injection in treatment of cerebral infarction wit h a multicenter studies

AIM:To study the efficacy of Panax notoginseng saporins injection in treating acute or chronic cerebral infarction. METHODS: Five hundred and eight two patients with cerebral infarction were divided into two groups randomly, Panax hotoginseng saporins group 291 patients (M 199, F 92; age 60 a± s 5 a) recieved Panax notoginseing saporins injection 400 mg in 500 mL of 5 % glucose or sodium chloride injection iv, drip, qd; ligustrazine group 291 patients (M 198, F 93; age 59 a±7 a) received ligustrazine injection 160 mg in 500 mL of 5% glucose or sodium chloride injection iv. drip, qd. The two groups showed the same therapeutic time as 30 d. RESULTS: The total response rate in the Panax notoginseing saporins injection group( 95.2 % ) was higher than that in the ligustrazine group (82.1 %,P<0.05). In addition, the former improved cerebrovasular hemodynamic parameters effectively. less adverse reactions were found. CONCLUSION: Panax notoginseng saporins injection is more effective and less adverse reaction than ligustrazine in treating cerebral infarction.