自身反应性T细胞与斑秃

斑秃的病因尚未完全清楚,但近年来多种研究表明,斑秃的发病与自身免疫有关,自身反应性T细胞在斑秃的发病中起着关键作用。综述自身反应性T细胞逃逸外周耐受、从外周血向毛囊迁移,及其介导斑秃发病的证据。研究斑秃自身反应性T细胞,有助于阐明斑秃的发病机制以及寻找有效及有针对性的治疗措施。

Autoreactive T Lymphocytes and Alopecia Areata

Although the precise etiology of alopecia areata has not been elucidated, an abundance of evidence recently supports an autoimmune pathogenesis for this common disorder. Autoreactive T cells play a key role in the pathogenesis of alopecia areata. This review focuses on the mechanisms of autoreactive T cells escaping peripheral tolerance, migration from blood to hair follicles, and evidence that alopecia areata is mediated by T cells. The study of autoreactive T cells in alopecia areata may help to elucidate the pathogenesis of the disease and search for effective and targeted treatment.