Heightened T-cell proliferation without an elevation of CD4+ T cell spontaneous apoptosis in AIDS patients |
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Authors: | Li Haiying Huang Xiaojie Guo Caiping Wang Wen Li Zaicun Zhang Tong Peng Qiaoli Chen Xinyue Wu Hao |
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Institution: | aDepartment of Infectious Diseases, Beijing You'an Hospital, Capital Medical University, China;bDepartment of Hepatology, Beijing You'an Hospital, Capital Medical University, China |
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Abstract: | T lymphocyte turnover has been studied extensively in HIV infection. The dynamic characteristics of various subsets of T cells in antiretroviral-naive, HIV-1-infected individuals, however, have not been well defined. Here, we performed a cross-sectional study using peripheral blood T cells from 39 antiretroviral-naive, chronically HIV-infected patients, as well as 16 healthy, HIV-negative controls. T-cell subset turnover rates were measured by Ki-67 antigen staining; levels of spontaneous apoptosis and activation in T-cell subsets were also determined by flow cytometry. Surprisingly, with disease progression, the level of T-cell spontaneous apoptosis did not increase significantly, despite a heightened rate of T-cell subset turnover and increased expression of the CD38 activation marker. These data refute the idea that increased T cell turnover is merely a homeostatic process in response to CD4 T cell loss during HIV disease progression, and suggest that future mechanistic studies may be needed for a comprehensive understanding of T-cell dynamics during HIV infection. Such understanding may help to develop new strategies for the immune modulation of clinical disease. |
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Keywords: | HIV-1 AIDS T cell Cell proliferation Apoptosis |
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