| 白细胞介素-4对哮喘患者血清IgE的影响 |
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| 引用本文： | 邓静敏,许辉,施焕中. 白细胞介素-4对哮喘患者血清IgE的影响[J]. 广西医科大学学报, 2000, 17(1): 65-66 |
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| 作者姓名： | 邓静敏 许辉 施焕中 |
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| 作者单位： | 广西医科大学第一附属医院呼吸内科!南宁530021 |
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| 摘 要： | 目的：探讨白细胞介素－４（ＩＬ－４）在过敏性支气管哮喘发病机制中对ＩｇＥ的作用。方法：试验采用双盲、交叉、随机、安慰剂对照的设计方法，给予８例过敏性哮患者吸入２０μｇ人重组ＩＬ－４或载体溶液，并分别于吸入前、吸入后２，２４，４８ｈ测定患者血清ＩｇＥ水平。结果：吸入载体溶液与吸入ＩＬ－４前的血清总ＩｇＥ基础值无显著差异（ｐ〉０．０５），吸入后各时点血清总ＩｇＥ亦无明显变化（ｐ〉０．０５）。结论：吸入
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| 关 键 词： | 白细胞介素4 IgE 气道高反应性 发病机制 哮喘 |
| 修稿时间： | 1999-03-16 |
THE EFFECT OF INHALED INTERLEUKIN-4 ON SERUM IgE LEVELS IN ASTHMATICS |
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| Deng Jingmin,Xu Hui,Shi Huanzhong. THE EFFECT OF INHALED INTERLEUKIN-4 ON SERUM IgE LEVELS IN ASTHMATICS[J]. Journal of Guangxi Medical University, 2000, 17(1): 65-66 |
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| Authors: | Deng Jingmin Xu Hui Shi Huanzhong |
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| Abstract: | Objctive:In order to investigate the role of interleuin 4 (IL 4) to IgE levels in asthmatics Methods:We investigated the effect of inhaled recombinant human IL 4 on serum IgE levels in eight patients with allergic bronchial asthma using a placebo controled study design,and determined IgE levels of these cases before inhalation and at 2,24,48 hours after inhalation Result:IL 4 inhalation did not cause any changes in serum IgE levels at any time throughout the study Conclusions:IL 4 induced airway hyperreactivity is not IgE dependent mechanism related |
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| Keywords: | interleukin 4 IgE airway hyperreactivity pathogenesis asthma |
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