聚乙二醇干扰素α-2b致低钾血症合并甲状腺功能减退症

1例36岁女性患者，因患慢性丙型肝炎给予聚乙二醇干扰素α-2b80μg皮下注射，1次／周。治疗期间出现流感样症状、白细胞减少，遂将聚乙二醇干扰素α-2b的剂量减为50μg皮下注射，1次／周。干扰素减量后，上述不良反应有所好转。治疗3个月，患者出现持续性低钾血症，检测肾功能及尿常规均正常。检测甲状腺功能，L0．53ng／ml，T43．35μg／dl，FT30．55pg／ml，FT40．00ng／dl，TSH〉100.0μU／ml。诊断为甲状腺功能减退症，停用聚乙二醇干扰素α-2b，给予甲状腺素及氯化钾治疗．甲状腺功能及血钾均恢复正常。

Hypopotassaemia and hypothyroidism induced by peginterferon α-2b

A 36-year-old woman with chronic hepatitis C was administered with peginterferon α-2b 80 μg once weekly by subcutaneous injection. The woman developed flu-like symptoms and leukopenia during treatment, Subsequently the dosage of peginterferon α-2b was decreased to 50 μg by subcutaneous injection once weekly, Her symptoms improved after decreasing the dosage of interferon. After 3 months of administration, she presented with persistent hypopotassaemia. Her renal function and urine routine tests were normal; her thyroid function examination showed the following values： T3 0.53 ng/ml, T4 3.35 μg/dl, FF3 0.55 pg/ml, FT4 0, 00 ng/dl, TSH 〉 100, 0 μU/ml, The patient was diagnosed with hypothyroidism. Peginterferon α-2b was stopped. Thyroxin and potassium chloride were given, Her thyroid function and serum potassium returned to normal limits.