西格列汀联合格列美脲治疗2型糖尿病的临床观察

目的探讨西格列汀联合格列美脲治疗2型糖尿病的疗效。方法将38例2型糖尿病患者随机分为二组，治疗组18例，用西格列汀联合格列美脲进行治疗，对照组20例应用格列美脲单药治疗，观察12周。比较二组患者治疗前后空腹血糖（FBG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlc）、低血糖发生率、体重指数（BMI）变化情况。结果治疗12周后，治疗组与对照组的FBG、2hPG、HbA1c、BMI均明显下降，但联合治疗组的各项指标更接近理想目标。结论西格列汀联合格列美脲治疗2型糖尿病疗效确切，且有效控制患者体重，但增加了低血糖事件发生率。

THERAPEUTIC EFFECT OF SITAGLIPTIN COMBINED WITH GLIMEPIRIDE IN TREATMENT OF TYPE 2 DIABETES

Objective To explore the clinical effect of Sitagliptin combined with Glimepiride in treatment of type 2 diabetes. Methods The thirtyeight diabetie patients were randomly devided into two groups, control group（20 cases） were given Glimepiride tablets, treatment group （18 cases）received Sitagliptin phosphate tablets for 12 weeks. The change of FPG, PPG, H bA1 c, hypoglycemia happen rate, weight were observed in two groups. Results Compared with pretherapy;the levels of FBG,2hPG, HbAlc,BMI were obviously descendent （P〈0.05）, but the elevels of markers were more approach their ideal goal in treatment group. Conclusion Sitagliptin conbined with Glimepiride can effectively control type 2 Diabetie patient＇s glucose and decrease weight gain, but increase the risk of hypoglycemia.