| 乳腺癌患者手术治疗前后血浆leptin和血清CA15-3、IL-8、hs-CRP检测的临床意义 |
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| 引用本文： | 刘大林,南云广,刘敬西,顾丹,刘伟.乳腺癌患者手术治疗前后血浆leptin和血清CA15-3、IL-8、hs-CRP检测的临床意义[J].放射免疫学杂志,2012,25(3):257-258. |
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| 作者姓名： | 刘大林 南云广 刘敬西 顾丹 刘伟 |
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| 作者单位： | 江苏省沭阳县仁慈医院,223600 |
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| 摘 要： | 目的:探讨乳腺癌患者手术治疗前后血浆leptin和血清CA15-3、IL-8、hs-CRP水平的变化及临床意义。方法:应用放射免疫分析和免疫比浊法对31例乳腺癌患者进行了手术治疗前后血浆leptin和血清CA15-3、IL-8、hs-CRP检测,并与35名正常人作比较。结果:乳腺癌患者在手术治疗前血浆leptin和血清CA15-3、IL-8、hs-CRP水平非常显著地高于正常人组(P<0.01),手术治疗后3个月则与正常人组比较无显著性差异(P>0.05)。结论:血浆leptin和血清CA15-3、IL-8、hs-CRP水平的变化在乳腺癌的发生和发展中相互作用,观察其浓度的变化对探讨乳腺癌的发病机理、预防和治疗均有重要的临床价值。
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| 关 键 词： | 乳腺癌 瘦素 糖类抗原15-3 白细胞介素-8 超敏C-反应蛋白 |
Clinical Significance of Determination of Changes of Plasma Leptin and Serum CA15-3, IL-8,hs-CRP Levels Both Before and After Operation in Patients with Breast Cancer |
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| Institution: | Liu Da-lin,Nan Yun-guang,Liu Jing-xi,et al. Shuyang Renci Hospital,Shuyang County(223600),China |
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| Abstract: | Objective To study the clinical significance of changes of plasma leptin and serum CA15-3,IL-8,hs-CRP levels after operation in patients with breast cancer.Methods Plasma leptin and serum IL-8,CA15-3(with RIA)serum hs-CRP(with immunoturbility method)levels were measured in 33 patients with breast cancer both before and after operation as well as in 35 normal controls.Results Before operation,plasma leptin and serum CA15-3,IL-8,hs-CRP levels were significantly higher than those in controls(P<0.01).3 months after operation,the plasma leptin and serum CA15-3,IL-8,hs-CRP levels in the patients were not particulary different from those in controls(P>0.05).Conclusion These cytokines participated in the pathogenesis of breast cancer and monitoring the serum levels might be helpful to the prevention management of such malignancies. |
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| Keywords: | breast cancer leptin CA15-3 interleukin-8(IL-8) hs-CRP |
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