牙周病患者血清hs-CRP、IL-8和IL-10检测的临床意义

目的：探讨牙周病患者血清hs-CRP、IL-8和IL-10水平的变化及临床意义。方法：应用放射免疫分析、酶联法和免疫比浊法对32例牙周病患者进行了血清hs-CRP、IL-8和IL-10检测,并与35名正常人作比较。结果：牙周病患者在治疗前血清hs-CRP、IL-8和IL-10水平均非常显著地高于正常人组（P〈0.01）,经治疗1个月后与正常人组比较仍有显著性差异（P〈0.05）。结论：检测血清hs-CRP、IL-8和IL-10水平的变化,对探讨牙周病发病机制、预防和指导治疗均有一定的临床价值。

Clinical Significance of Measurement of Serum hs-CRP,IL-8 and IL-10 Levels in Patients with Periodontitis

Objective To explore the significance of changes on serum hs-CRP,IL-8 and IL-10 levels in patients with periodontitis.Methots Serum hs-CRP(with immuno-turbidimetry),IL-8(with RIA),IL-10(with ELISA) levels were measured in 32 patients with periodontitis both before and after treatment as well as in 35 normal controls.Results Before treatment serum levels of hs-CRP,IL-8 and IL-10 were extremely higher in the patients than those in controls(P<0.01).After one month of treatment,the serum hs-CRP,IL-8 and IL-10 levels decreased but still significantly higher than those in controls(P<0.05) Conclusion Determination of Changes of serum hs-CRP,IL-8 and IL-10 levels has definite value to study pathogenesis,prevention and guide the therapeutic effect in patients with periodontitis.