脑外伤患者血浆D-D、CRP和Fb的检测及临床观察

目的:揭示脑外伤患者血浆D-二聚体(D-D)、C-反应蛋白(CRP)和纤维蛋白原(Fb)浓度,分析其与预后的相关性。方法:收集脑外伤患者86例及对照组30例,检测血浆D-D、CRP和Fb浓度,统计分析其与预后的相关性。结果:脑外伤患者入院后1个月内死亡20例(23.3%)。脑外伤患者血浆D-D、CRP和Fb浓度较对照组明显升高(P<0.01),非生存患者血浆D-D、CRP和Fb浓度较生存患者明显升高(P<0.01),血浆D-D、CRP和Fb浓度预测脑外伤后1个月内死亡均有较高的灵敏度和特异度(P<0.01)。结论:D-D、CRP和Fb共同参与了脑外伤的病理生理过程,该些标志物适合作为一种常规的甄别方法,临床检测这些指标有助于早期预测脑外伤后1个月内死亡的评估。

Determination of Plasma D-dimer, C-reactive Protein and Fibrinogen Concentrations in Patients with Traumatic Brain Injury and Their Clinical Observation

Objective This study aimed to determine the levels of plasma D-dimer,C-reactive protein,and fibrinogen in patients with traumatic brain injury and to correlate their levels with disease outcome.Methods 30 healthy controls and 86 patients with traumatic brain injury were included.Concentrations of the plasma D-dimer,C-reactive protein,and fibrinogen were measured.Their associations with disease outcome were analyzed statistically.Results 20(23.3%) patients died in a month after traumatic brain injury.The plasma D-dimer,C-reactive protein,and fibrinogen levels were significantly higher than those in healthy controls(P<0.01),were particulary higher in the non-survivals than in survivals(P<0.01),and predicted 1-month mortality of patients with the high sensitivity and specificity values(all P<0.01).Conclusion D-dimer,C-reactive protein,and fibrinogen may contribute to the pathophysiologic process of traumatic brain injury.These markers are suitable to be used as a general screening method and their plasma levels can be served as useful clinical markers for evaluating 1-month mortality of patients with traumatic brain jury.