饮水不同碘水平对儿童甲状腺功能的影响

目的探讨饮水不同碘水平对儿童甲状腺功能的影响。方法选择饮水碘不同的3个地区作为调查点,以当地出生成长的7～13岁儿童作为调查对象;砷铈催化分光光度法测定尿碘含量。B超检查儿童甲状腺,并按照《GB16004-1995》中甲状腺肿大的诊断标准诊断甲状腺肿大情况;放射免疫分析法测定血清中游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(hTSH)3种激素水平。结果不同碘水平地区儿童尿碘中位数分别为高水碘区461.41 mg/L、中等水碘区348.80 mg/L和较低水碘区265.01 mg/L,3组比较差异有统计学意义(P<0.05);高水碘区儿童血清FT3浓度中位数为4.02 pmol/L,低于较低水碘区儿童5.50 pmol/L,两者差异有统计学意义(P<0.05);3组儿童血清FT4、hTSH水平及甲状腺肿大率差异均无统计学意义(P>0.05)。结论饮水高碘可能影响儿童血清FT3浓度。

Influence of different iodine concentration in drinking water on the function of children's thyroid

Objective To investigate the influence of different iodine level in drinking water on the function of children’s thyroid.Methods On the basis of epidemiology survey,children aged from 7～13 years old were recruited from three villages with different iodine level in drinking water.Iodine concentrations in urine were measured with arsenic cerium oxide catalytic spectrophotometric method.The concentration of serum FT3、FT4 and hTSH were determined using radioimmunoassay method.Results Urinary iodine median were 461.41 mg/L in children from high iodine drinking water village,348.80 mg/L in children from moderate iodine drinking water village and 265.01 mg/L in children from relative lower iodine drinking water village.There was significant difference among these three groups(P<0.05).Serum FT3 level in children from high iodine drinking water village was higher than that from relative lower iodine drinking water village(P<0.05).No significant differences were observed of serum FT4 and hTSH in children from the three villages(P>0.05).The prevalence of children’s goiter in three villages was not significant difference(P> 0.05).Conclusion High iodine may influence serum FT3 level.