COPD患者血清IL-6、IL-8、hs-CRP和IL-18检测的临床意义

目的：观察慢性阻塞性肺疾病（COPD）患者治疗前后血清IL-6、IL-8、hs-CRP和IL-18水平的变化及临床意义。方法：应用放射免疫分析和免疫比浊法对32例COPD患者进行了治疗前后血清IL-6、IL-8、hs-CRP和IL-8检测,并与35名正常健康人作比较。结果：COPD患者在治疗前血清IL-6、IL-8、hs-CRP和IL-18水平均非常显著地高于正常人组（P〈0.01）,经中西医结合治疗1个月后与正常人组比较仍有差异（P〈0.05）。结论：IL-6、IL-8、hs-CRP和IL-18的测定,可适用为一种筛选方法,其变化可能以不同的方式参与了COPD的发病,此外,该些项目的检测对了解病情、指导治疗具有重要的临床价值。

Clinical Relevance of Determination the Changes on Serum IL-6, IL-8,hs-CRP and IL-18 Levels in Patients with Chronic Obstructive Pulmonary Diseases(COPD)

Objective To observe the clinical significance of changes on serum IL-6,IL-8,hs-CRP and IL-18 levels after treatment in patients with COPD.Methods Serum Il-6,IL-8(with RIA),serum hs-CRP(with immunotubidimetry) levels were measured both before and after treatment in 32 patients with COPD as well as in 35 normal controls.Results Before treatment,the serum IL-6,IL-8,hs-CRP,IL-18 levels were significantly higher than those in controls(P<0.01).After 1 month of treatment the serum IL-6,IL-8,hs-CRP and IL-18 dropped markedly but remained higher difference than those in controls(P<0.05).Conclusion Measurement of serum IL-6,IL-8,hs-CRP and IL-18 were suitable to be used as a screening method.Besides,it could take part in pathogenesis of COPD in various ways and the changes of these items levels is of important values to realize pathosis and therapeutic effect.