卵巢癌患者手术治疗前后血清CA125、Hcy和HE4检测的临床意义

目的：探讨卵巢癌患者手术治疗前后血清CA125、Hcy和HE4水平的变化及临床意义。方法：应用放射免疫分析、酶联法和免疫法对38例卵巢癌患者进行了手术治疗前后血清CA125、Hcy和HE4检测,并与35名正常健康人作比较。结果：卵巢癌患者在手术治疗前血清CA125、Hcy和HE4水平均非常显著地高于正常人组（P〈0.01）,术后6个月未复发的33例明显下降接近于正常人组,而复发的5例,其值又回升至手术前水平（P〈0.01）。结论：检测卵巢癌患者手术治疗前后血清CA125、Hcy和HE4水平的变化有助于诊断和疗效观察。此外,该类实验室标志物更适用作为参考。

Clinical Significance of Measurement the Changes of Serum CA125,Hcy and HE4 Levels After Operation in Patients with Ovarian Cancer

Objective To study the changes of serum CA125,Hcy and HE4 levels after operation in patients with ovarian cancer.Methods Serum CA125(with RIA) serum Hcy(with immuno-chemistry)serum HE4(with ELISA) levels were determined in 38 patients with ovarian cancer both before and after operation as well as in 35 normal healthy controls.Resulotion Before operation,serum CA125,Hcy and HE4 levels in patients were significantly higher than those in controls(P<0.01).After operation in 33 cases without recurrence at 6 months,the levels remained dropped markedly and approached levels in controls.However in 5 patients with recurrence,the levels increased again,approaching those before operation.Conclusion Serum levels of CA125,Hcy and HE4 might be usefull for diagnosis and predicting therapeutic efficacy after operation in patients with ovarian cancer.Furthermore,such laboratory markers more suitable for reference.