孟鲁司特对支气管哮喘患者血清IL-6、IL-8和IL-10水平的影响

目的:探讨孟鲁司特在支气管哮喘患者体内IL-6、IL-8和IL-10水平的影响。方法:应用放射免疫分析和酶联法对31例支气管哮喘患者应用孟鲁司特治疗前后血清IL-6、IL-8和IL-10水平的变化,并与35名正常健康人作比较。结果:支气管哮喘患者在治疗前血清IL-6、IL-8水平非常显著地高于正常人组(P<0.01),而IL-10水平显著地低于正常人组(P<0.01),经治疗2周后与正常人组比较仍有显著性差异(P<0.05)。结论:孟鲁司特对支气管哮喘患者血清IL-6、IL-8和IL-10有一定程度的调节作用,从而降低患者体内的炎症水平,促进病情缓解和好转。

The Effect of Montelukast on the Levels of IL-6,IL-8 and IL-10 in Patients with Bronchial Asthma

Objective To explore the effect of Montelukast on serum IL-6,IL-8 and IL-10 levels in patients with bronchial asth- ma. Methods Serum IL-6,IL-8 （with RIA） ,IL-10 （with ELISA） levels were meassured in 31 patients after Montelukast treatment with bronchial asthma as well as in 35 normal healthy controls. Result Before treatment serum IL-6, IL-8 levels in the asthma group were significantly higher than those in controls （P 〈 0.01 ）. While the IL-10 level was undoubtedly lower than that in the controls （P 〈 0.01 ）. After treatment, the serum IL-6, IL-8 and IL-10 levels were still significantly （ P 〈 0.05）. Conclusion Montelukast treatment could bring about some regulatory effect on serum IL-6, IL-8 and IL-10 levels in patients with asthma and furthermore reducing the severity of inflammation and enhancing remission.