肝硬化患者血清TPO水平与APN和HA水平相关性探讨

目的：探讨肝硬化患者血清血小板生成素（TPO）水平与脂联素（APN）和HA的相关性。方法：应用放射免疫分析和酶联法对63例肝硬化患者进行血清TPO、APN和HA检测,并与35名正常健康人作比较。结果：肝硬化患者血清TPO、APN水平均非常显著地低于正常人组（P〈0.01）,而HA水平则显著地高于正常人组（P〈0.01）,血清TPO水平与APN水平呈正相关（r=0.6284,P〈0.01）,与HA水平呈负相关（r=-0.4982,P〈0.01）。结论：肝硬化患者血清TPO、APN和HA水平与疾病的发生、发展密切相关,有重要的临床价值。

The Study of Correlativity Between Serum Thrombopoietin(TPO) Level and Adiponectin, HA Levels in Patients with Hepatic Cirrhosis

Objective To explore the relationship between serum TPO and adiponectin,HA levels in patients with hepatic cirrhosis.Methods Serum adiponectin,HA(with RIA) serum TPO(with ELISA) levels were measured in 63 hepatic cirrhosis patients and 35 controls.Results Serum TPO and adiponectin levels in patients were significantly lower than those in controls(P<0.01),while the serum HA were remarkably higher(P<0.01).Serum TPO level is positive correlated with adiponectin(r=0.6284,P<0.01),and TPO is negative correlated with HA(r=0.4982,P<0.01).Conclusion Development and progression of hepatic cirrhosis is closely related to the serum TPO,adiponectin HA levels,hence offers important clinical value.