急性颅脑损伤患者血清NSE、IL-8和CNP水平的变化及临床意义

目的：探讨了急性颅脑损伤患者治疗前后血清NSE、IL-8和CNP水平的变化及临床意义。方法：应用放免法对30例急性颅脑损伤患者进行了血清NSE、IL-8和CNP的检测,并与35名正常健康人作比较。结果：急性颅脑损伤患者在治疗前血清NSE、IL-8水平非常显著地高于正常人组,而CNP水平又非常显著地低于正常人组（P〈0.01）。经治疗2周后则与正常人组比较无显著性差异（P〉0.05）,且血清NSE水平与IL-8水平呈正相关（r=0.6188,P〈0.01）,与CNP水平呈显著负相关（r=-0.578,P〈0.01）。结论：检测血清NSE、IL-8和CNP水平的变化有助于估计急性颅脑损伤患者病情的轻重及预后。

Clinical Significance of Changes of Serum NSE,IL-8 and CNP Levels in Patients with Acute Craniocerebral Injury

Objective To explore the clinical significance of changes of serun NSE,IL-8 and CNP levels after treatment in patients with acute craniocerebral injury.Methods Serum NSE,IL-8 and CNP levels with RIA in 30 patients with acute craniocerebral injury and 35 normal healthy controls.Results Before treatment,serum NSE and IL-8 levels in patients with acute craniocerebral injury were significantly higer than those in controls(P<0.01).But the serum CNP levels were apparently lower(P<0.01).After treatment for 2 weeks.The levels were approaching normal(P>0.05).Serum NSE level was positive correlated to serum IL-8(r=0.6188,P<0.01).While negative correlated with CNP level(r=-0.5782,P<0.01).Conclusion Detection of serun NSE,IL-8 and CNP levels might be helpful for assessment of the severity of disease process and prognosis.