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| 乌拉地尔在大鼠小肠的在体灌流吸收研究 | |
| 引用本文： | 丛军兹,王宝庆,缪淑霞,时薛丽,颜娟娟,马满玲,高文远. 乌拉地尔在大鼠小肠的在体灌流吸收研究[J]. 中国药房, 2008, 19(22): 1712-1714 |
| 作者姓名： | 丛军兹 王宝庆 缪淑霞 时薛丽 颜娟娟 马满玲 高文远 |
| 作者单位： | 1. 牡丹江医学院附属第一医院药剂科,牡丹江市,157011 2. 天津大学药物科学与技术学院,天津市,300072 3. 佳木斯医学院附属第一医院药剂科,佳木斯市,154002 4. 哈尔滨医科大学第一医院药剂科,哈尔滨市,150000 |
| 摘 要： | 目的:研究乌拉地尔在大鼠小肠上、下部的吸收情况,为开发其缓释制剂提供依据。方法:采用大鼠在体小肠回流实验装置,利用高效液相色谱法分别测定酚红和乌拉地尔的含量。结果:乌拉地尔在大鼠小肠上、下段的吸收速度常数Ka分别为0.269、0.271,t1/2分别为2.6、2.58h,吸收率分别为27.29%、28.26%(P>0.05)。结论:乌拉地尔在大鼠小肠上、下段的吸收率无显著性差异,适合制备缓释制剂。 |
| 关 键 词： | 乌拉地尔 大鼠 小肠 高效液相色谱法 在体灌流 |
In Situ Recirculation of Urapidil In Rat''s Intestine |
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| Affiliation: | CONG Jun-zi, SHI Xue-li, WANG Bao-qing, YAN Juan-juan, GAO Wen-yuan, MIAO Shu-xia, MA Man-ling( Dept. of Pharmacy, The First Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157011, China; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Dept. of Pharmacy, The First Affiliated Hospital of Jiamusi Medical College, Jiamusi 154002, China; Dept. of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China) |
| Abstract: | OBJECTIVE： To study the absorption of urapidil in upper and lower rat＇ s small intestine for reference of developiing sustained release preparation of urapidil. METHODS： The intestine in rats was cannulated for in situ recirculation. HPLC was used to determine the concentrations of phenolsulfonphthalein and urapidil. RESULTS： In upper and lower rat＇s small intestine, Ka（h 1） were 0,269 and 0.271, t1/ 2（h） 2.6 and 2.58, and the percent of absorption 27.29% and 28.26%, respectively （P 〉0.05）. CONCLUSION： There was no significant difference between upper and lower rat＇s small intestine in the percent of absorption of urapidil and which thus suitable to be prepared into sustained release preparation. |
| Keywords: | Urapidil Rat Intestine HPLC In vivo recirculation |
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