| CD137与系统性红斑狼疮 |
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| 引用本文： | 王茜,叶冬青. CD137与系统性红斑狼疮[J]. 疾病控制杂志, 2005, 9(6): 630-633 |
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| 作者姓名： | 王茜 叶冬青 |
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| 作者单位： | 安徽医科大学公共卫生学院流行病与卫生统计学系,安徽,合肥,230032 |
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| 摘 要： | 系统性红斑狼疮是自身免疫性疾病的原型,主要表现为T、B淋巴细胞功能异常,产生大量自身抗体,近年来发现,T细胞及其亚群和共刺激分子可能是SLE的发病机制的关键.本文就共刺激分子CD137的结构、配体、生物学功能及其在系统性红斑狼疮发生、发展中的作用作一综述.
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| 关 键 词： | 红斑狼疮 系统性 T淋巴细胞 |
| 文章编号： | 1008-6013（2005）06-0630-04 |
| 收稿时间： | 2005-08-25 |
| 修稿时间： | 2005-08-25 |
CD137 and systemic lupus erythematosus |
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| WANG Qian,YE Dong-qing. CD137 and systemic lupus erythematosus[J]. Chinese Journal of Disease Control and Prevention, 2005, 9(6): 630-633 |
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| Authors: | WANG Qian YE Dong-qing |
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| Abstract: | Systemic lupus erythematosus(SLE) is prototype of autoimmune disease characterized by disfunction of T cell and B cell and the occurrence of numerous autoantibodies directed against nuclear antigens.In recent years,T cell,its subsets and costimulator may play important role in the process of SLE.The structure of CD137,its ligand,its function in SLE are reviewed. |
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| Keywords: | Lupus erythematosus, systemic T-lymphocytes |
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