| X射线照射致皮质发育障碍模型大鼠致癫性的研究 |
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| 引用本文： | 张建刚,宋延波,张毅,黄敏,冯占辉,贺兴,晏勇. X射线照射致皮质发育障碍模型大鼠致癫性的研究[J]. 第三军医大学学报, 2011, 33(1): 74-77 |
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| 作者姓名： | 张建刚 宋延波 张毅 黄敏 冯占辉 贺兴 晏勇 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科;重庆医科大学附属第一医院肿瘤科; |
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| 摘 要： | 目的 建立X射线照射诱导皮质发育障碍模型,运用快速杏仁核点燃等方法探讨其癫痫易感性等相关特性及测试癫痫易感性的方法.方法 6只SD孕鼠按需要完全随机分为实验组和正常对照组.实验组:在孕16 d采用直线加速器进行X射线照射制作皮质发育障碍模型;正常对照组:不做任何处理.选取P60 d仔鼠,观察一般行为学和大脑外形,HE...
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| 关 键 词： | X射线 皮质发育障碍 癫痫易感性 快速杏仁核点燃 |
Study of seizure susceptibility in rat model of X-ray irradiation-induced disorder of cortical development |
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| Zhang Jiangang,Song Yanbo,Zhang Yi,Huang Min,Feng Zhanhui,He Xing,Yan Yong. Study of seizure susceptibility in rat model of X-ray irradiation-induced disorder of cortical development[J]. Acta Academiae Medicinae Militaris Tertiae, 2011, 33(1): 74-77 |
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| Authors: | Zhang Jiangang Song Yanbo Zhang Yi Huang Min Feng Zhanhui He Xing Yan Yong |
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| Affiliation: | Zhang Jiangang1,Song Yanbo2,Zhang Yi1,Huang Min1,Feng Zhanhui1,He Xing1,Yan Yong1(1Department of Neuro-logy,First Affiliated Hospital,Chongqing Medical University,2Department of Oncology,Chongqing,400016,China) |
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| Abstract: | Objective To establish the rat model of X-ray irradiation-induced disorder of cortical development,and to investigate its correlation with seizure susceptibility.Methods Six pregnant SD rats were randomly divided into an experimental group and a control group.In the experimental group,the rat model of X-ray irradiation-induced disorder of cortical development was produced on the 16th day of pregnancy with a linear accelerator.The control group was kept without any treatment.The P60d offspring rats were sele... |
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| Keywords: | X-ray disorder of cortical development seizure susceptibility rapid amygdala kindling |
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