| 兔间充质干细胞在Vanco-AB-FG三维支架中的增殖和分化 |
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| 引用本文： | 边巴罗布,侯天勇,吴雪晖,许建中.兔间充质干细胞在Vanco-AB-FG三维支架中的增殖和分化[J].第三军医大学学报,2011,33(1):9-13. |
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| 作者姓名： | 边巴罗布 侯天勇 吴雪晖 许建中 |
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| 作者单位： | 第三军医大学西南医院骨科全军矫形外科中心; |
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| 基金项目： | 国家高技术研究发展计划重大专项(863计划,2006AA02A122); 国家自然科学基金(30900312); 全军医学科研“十一五”计划专项(08Z026); 第三军医大学青年创新人才基金(2009XQN23)~~ |
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| 摘 要： | 目的 观察兔间充质干细胞(mesenchymal stem cells derived from bone marrow,BMSCs)在带有万古霉素藻酸盐微球的纤维蛋白凝胶(vancomycin alginate beads embedded in fibrin gel,Vanco-AB-FG)中增殖和成骨分化情况.方...
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| 关 键 词： | 组织工程骨 抗生素缓释 骨组织感染 可注射凝胶 |
Experimental study on proliferation and osteogenic differentiation of rabbit BMSCs in 3D scaffold of vancomycin alginate beads embedded in fibrin gel |
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| Bian Baluobu,Hou Tianyong,Wu Xuehui,Xu Jianzhong.Experimental study on proliferation and osteogenic differentiation of rabbit BMSCs in 3D scaffold of vancomycin alginate beads embedded in fibrin gel[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(1):9-13. |
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| Authors: | Bian Baluobu Hou Tianyong Wu Xuehui Xu Jianzhong |
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| Institution: | Bian Baluobu,Hou Tianyong,Wu Xuehui,Xu Jianzhong(Department of Orthopedics,Orthopedics Center of PLA,Southwest Hospital,Third Military Medical University,Chongqing,400038,China) |
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| Abstract: | Objective To observe the proliferation and osteogenic differentiation of mesenchymal stem cells derived from rabbit bone marrow(BMSCs) in the 3D scaffold of vancomycin alginate beads embedded in fibrin gel(Vanco-AB-FG).Methods BMSCs were derived from healthy adult rabbits through gradient centrifugation and adherent culture.In the experimental group,BMSCs were suspended in a fibrinogen solution,and then injected into Vanco-AB-FG to construct tissue engineered bones.In the control group,BMSCs were seeded on ... |
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| Keywords: | tissue-engineered bone antibiotic controlled release osseous tissue infection injectable fibrin gel |
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