| 新辅助化疗对肌层浸润性膀胱癌预后影响的Meta分析 |
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| 引用本文： | 樊晓栋,姜庆,王家武.新辅助化疗对肌层浸润性膀胱癌预后影响的Meta分析[J].第三军医大学学报,2011,33(2):196-199. |
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| 作者姓名： | 樊晓栋 姜庆 王家武 |
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| 作者单位： | 重庆医科大学附属第二医院泌尿外科; |
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| 摘 要： | 目的评价新辅助化疗对肌层浸润性膀胱癌患者预后的影响。方法通过PubMed、Cochrane library、万方、康健、CBMdisc、EMBASE等数据库收集国内外已发表的相关前瞻性随机对照研究,按预设的标准进行筛选,共12个研究符合纳入标准,总样本量3286例,新辅助治疗组1636例,对照组1650例,对纳入研究进行质量评价,并提取数据进行Meta分析。结果新辅助化疗组与对照组相比,死亡风险优势比0.85(95%CI0.73～0.98,P=0.03)。将12个纳入研究按新辅助化疗方案进行亚组分析,单用铂剂组显示新辅助化疗并没有降低患者死亡风险,而以铂剂为基础的多药联合新辅助化疗可降低患者死亡风险(OR0.79,95%CI0.67～0.92,P=0.0004)。结论新辅助化疗,尤其是以铂剂为基础的联合化疗方案,适用于肌层浸润性膀胱癌的治疗,可改善预后。
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| 关 键 词： | 新辅助化疗 肌层浸润性膀胱癌 Meta分析 |
Efficacy of neoadjuvant chemotherapy on prognosis of muscle-invasive bladder cancer: a Meta-analysis study |
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| Fan Xiaodong,Jiang Qing,Wang Jiawu.Efficacy of neoadjuvant chemotherapy on prognosis of muscle-invasive bladder cancer: a Meta-analysis study[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(2):196-199. |
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| Authors: | Fan Xiaodong Jiang Qing Wang Jiawu |
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| Institution: | Fan Xiaodong,Jiang Qing,Wang Jiawu(Department of Urology,Second Affiliated Hospital,Chongqing Medical University,Chongqing,400016,China) |
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| Abstract: | Objective To evaluate the effect of neoadjuvant chemotherapy on the prognosis of muscle-invasive bladder cancer.Methods Published prospective randomized controlled trials(RCT) on neoadjuvant chemotherapy for muscle-invasive bladder cancer were searched and screened in Pubmed,EMBASE,CBMdisc,Cochrane library and Wanfang databases under preset standards.The data from eligible studies were pooled through Meta-analysis.Results Totally 12 trials including 3 286 patients were eligible to the criteria(1 636 in stud... |
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| Keywords: | neoadjuvant chemotherapy muscle-invasive bladder cancer Meta-analysis |
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