| Abstract: | The incidence and transplantability of ovarian teratoma in LT/Sv mice were examined following cisplatin treatment at the age of 16 days, and compared to those in the control group. Cisplatin had not affected the emergence of egg cleavage, which simultaneously appeared in the mouse ovaries in both groups. Although 7 teratomas, occasionally transplantable, developed in the control mice aged over 30 days, only 2 tumors occurred in cisplatin-treated mice at the age of 120 days and they were not transplantable. The results suggest that cisplatin might influence the tumorigenic process after egg cleavage, or transplantability of teratoma. |
